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One of the holy grails in biology is the ability to predict functional characteristics from an organism’s genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism’s phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from “-omics” screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
Contents
- The National Academies of SCIENCES • ENGINEERING • MEDICINE
- PLANNING COMMITTEE ON NEXT STEPS FOR FUNCTIONAL GENOMICS: A WORKSHOP
- BOARD ON LIFE SCIENCES
- Reviewers
- 1. Introduction
- 2. The Genotype–Phenotype Challenge
- 3. Case Studies on Building Functional Genomics Tools in Diverse Systems
- 4. Understanding the Contributions of Non-Protein-Coding DNA to Phenotype
- 5. Advancing Research on the Environmental Regulation of Gene Function
- 6. Predicting Current and Future Sources of Variation in Quantitative Traits
- 7. Interpreting and Validating Results from High-Throughput Screening Approaches
- LESSONS ON DESIGN AND VALIDATION FROM A CRISPR LOSS-OF-FUNCTION SCREEN ON KRAS-MUTANT CANCERS
- USING FUNCTIONAL GENOMICS TO UNDERSTAND DEVELOPMENT
- VALIDATING RESULTS FROM HIGH-THROUGHPUT ENHANCER SCREENS
- HARNESSING GENETIC DIVERSITY TO UNDERSTAND MAINTENANCE OF PLURIPOTENCY IN EMBRYONIC STEM CELLS
- DISCUSSION
- 8. Large Databases and Consortia
- 9. Big-Picture Challenges in Research, Education, and Training
- 10. Future of Functional Genomics
- References
- Appendix A. Statement of Task
- Appendix B. Workshop Agenda
- Appendix C. Planning Committee Biographies
- Appendix D. Speaker Biographies
- Appendix E. Acronyms and Abbreviations
Suggested citation:
National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/25780.
Digital Object Identifier: https://doi.org/10.17226/25780
Additional copies of this publication are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.
Printed in the United States of America
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